PANAFIL® Ointment - Mode of Action  

1. Papain - urea benefits
  • Proteolytic activity removes non-viable protein that may impede wound healing.
  • Enhances Chlorophyllin Copper Complex access to granulating tissue.

2. Chlorophyllin Copper Complex Mode of Action**
  

• Fibrin inhibits blood flow and nutrients to the wound site. (above)


• Chlorophyllin Copper Complex (CCC) reduces fibrin formation. Macrophages arrive and signal fibroblasts to initiate collagen deposition. (above)


• The copper in CCC enhances structural integrity of the deposited collagen matrix

**1. Miller, J.M.: The Interaction of Papain, Urea and Water-Soluble Chlorophyll in a Proteolytic Ointment for Infected Wounds, Surgery 43:939, 1958.
2. Smith, L.W.: The Present Status of Topical Chlorophyll Therapy, New York J. Med. 55:2041, 1955.
3. Barnard, R.D.: Elucidation of Chemically Defined Haptens For Competitive Inhibition of Aggressin Activity. Immunol. 8:78, 1954.


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