Q: How does ACCUZYME compare with other enzymes?

A: ACCUZYME is substrate non-specific - meaning it has the ability to debride all types of non-viable proteins (fibrin, collagen, nucleoproteins etc.) - versus being substrate specific, thus having the ability to debride only certain types of non-viable matter such as collagen.

Q: What pH range is optimal for ACCUZYME activity?

A: ACCUZYME is active in a broad wound pH of 3 to 12. Other commercially available enzyme debriding preparations have pH ranges in which the enzyme�s optimal range is narrower. According to published information, higher or lower pH ranges will decrease the enzyme�s activity and appropriate precautions should be taken.

Q: How often should ACCUZYME dressings be changed?

A: ACCUZYME should be changed daily or may be changed twice daily.

Q: How soon will I begin to see results with ACCUZYME?

A: The effects of ACCUZYME are usually observable within a few days, depending upon the type of wound and the type of necrosis present.

Q: Other enzymes claim to be specific to the type of substrate they will digest. What substrate will ACCUZYME digest?

A: ACCUZYME is substrate non-specific. This means ACCUZYME will digest all non-viable substrates found in necrosis rather than simply one or two.

A: ACCUZYME DOES NOT HARM VIABLE TISSUE. Sensitization studies performed on healthy volunteers show ACCUZYME to be harmless to viable tissue.

Q: Does ACCUZYME require the use of a topical antibiotic in infected necrotic wounds?

A: No. ACCUZYME is capable of, and indicated for, digesting necrotic tissue in the presence of infection.

Q: How should the wound be cleansed prior to application of ACCUZYME?

A: AllClenz™ Wound Cleanser has been shown to be an ACCUZYME-compatible surfactant wound cleansing agent for removing debris from the wound bed. Normal saline would be a suitable alternative. Avoid cleansing with hydrogen peroxide solution as it may inactivate the papain.

Q: What cover dressing should be used with ACCUZYME?

A: ACCUZYME should be covered with an appropriate dressing of choice. We recommend placing a moistened gauze dressing topped with a dry gauze dressing over the wound following the application of ACCUZYME.